Stage IIIB TNM Any T, N3, M0 or T4, any N, M0 The tumor cannot be removed because of technical reasons or because there would be no benefit to the patient. Standard Treatment These tumors are best managed with radiation therapy . Surgery usually has no benefit at this stage. Five-Year Survival Less than 5 percent Investigational • Trials are examining the effectiveness of chemotherapy and/or radiation therapy before surgery. These treatments have occasionally converted some patients to an operable stage, but it is too soon to know if using this aggressive approach will increase the rate of cure.